Novel pyridine‐bis(ferrocene‐isoxazole) ligand: synthesis and application to palladium‐catalyzed Sonogashira cross‐coupling reactions under copper‐ and phosphine‐free conditions | Zendy

Feng Zhijun | Zendy; Yu Shuyan | Zendy; Shang Yongjia | Zendy

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Novel pyridine‐bis(ferrocene‐isoxazole) ligand: synthesis and application to palladium‐catalyzed Sonogashira cross‐coupling reactions under copper‐ and phosphine‐free conditions

Author(s) -

Feng Zhijun,

Yu Shuyan,

Shang Yongjia

Publication year - 2008

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1445

Subject(s) - chemistry , sonogashira coupling , phosphine , isoxazole , pyridine , ferrocene , palladium , ligand (biochemistry) , aryl , coupling reaction , combinatorial chemistry , copper , medicinal chemistry , polymer chemistry , catalysis , halide , organic chemistry , alkyl , receptor , biochemistry , electrode , electrochemistry

We present here the first synthesis and application to Sonogashira reaction of pyridine‐bis(ferrocene‐isoxazole) Pd(II) complex 5 , prepared from 2,6‐bis‐(5‐ferrocenylisoxazole‐3‐yl)pyridine. Under copper‐ and phosphine‐free conditions, the stable complex 5 efficiently catalyzed the cross‐coupling of aryl halides with terminal alkynes in DMF–H 2 O with TBAB as an additive, hexahydropyridine as base and affording internal arylated alkynes in moderate to excellent yields. Copyright © 2008 John Wiley & Sons, Ltd.

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