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Niobium(V) chloride‐catalyzed synthesis of α‐aminonitriles with simultaneous reaction of aldehydes, amines and trimethylsilyl cyanide
Author(s) -
Majhi Anjoy,
Kim Sung Soo,
Kim Ho Sub
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1427
Subject(s) - chemistry , trimethylsilyl cyanide , catalysis , cyanide , trimethylsilyl , chloride , organic chemistry , trimethylsilyl chloride , niobium , reaction conditions , medicinal chemistry
A simple and efficient one‐pot method has been developed for the synthesis of α‐aminonitriles by concurrent reaction of aldehydes, amines and trimethylsilyl cyanide with a catalytic amount of NbCl 5 (10 mol%) in CH 3 CN at room temperature. Copyright © 2008 John Wiley & Sons, Ltd.