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Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes
Author(s) -
Patel M. N.,
Pansuriya P. B.,
Chhasatia M. R.
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1417
Subject(s) - chemistry , serratia marcescens , bacillus subtilis , ligand (biochemistry) , denticity , bacillus cereus , schiff base , metal , binding constant , titration , nuclear chemistry , stereochemistry , inorganic chemistry , escherichia coli , binding site , organic chemistry , bacteria , biochemistry , receptor , genetics , biology , gene
The mixed‐ligand complexes of iron(III) with 1‐cyclopropyl‐6‐fluoro‐4‐oxo‐7‐piperazin‐1‐yl‐1,4‐dihydroquinoline‐3‐carboxylic acid and various neutral bidentate Schiff base ligands were prepared. The structure of mixed‐ligand complexes was investigated using spectral, physicochemical and elemental analyses. Biocidal activity was determined using agar plate technique against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Escherichia coli and Serratia marcescens . The result showed a significant increase in a biocidal activity compared with parent ligands, metal salts and standard drugs (ofloxacin, levofloxacin). DNA binding and cleavage studies were carried out using absorption titration and gel electrophoresis techniques, respectively. The binding constant of Fe(III) complexes was obtained in the range 2.5–4.0 × 10 4 M −1 . The DNA binding and cleavage efficacy were raised in mixed‐ligand complexes as compared with parental ligands and metal salts. Copyright © 2008 John Wiley & Sons, Ltd.