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Modifying the structure of dinuclear ruthenium complexes with antitumor activity
Author(s) -
MendozaFerri Maria G.,
Hartinger Christian G.,
Nazarov Alexey A.,
Kandioller Wolfgang,
Severin Kay,
Keppler Bernhard K.
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1394
Subject(s) - chemistry , ruthenium , stereochemistry , ring (chemistry) , nuclear magnetic resonance spectroscopy , medicinal chemistry , organic chemistry , catalysis
In order to modulate the structure of a recently developed series of antitumor‐active, dinuclear Ru(II)–arene compounds, complexes 1c – 4c were synthesized. The complexes were modified with respect to their pyridinone moieties and the spacer linking the two metal centers. More particularly, the series of dinuclear ruthenium(II) complexes was extended to compounds with longer spacers, i.e. tetradecane and 3,7,10‐trioxotridecane, and the pyridinone ring was modified by replacing the methyl group by an ethyl group and by shifting the position of the methyl group. The organometallic ruthenium compounds were obtained from the reaction between [RuCl 2 (η 6 ‐ p ‐isopropyltoluene)] 2 and ligands 1b – 4b with yields ranging from 41 to 67%. All compounds were characterized by standard methods: MS, 1 H and 13 C NMR spectroscopy and elemental analysis. Copyright © 2008 John Wiley & Sons, Ltd.