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Synthesis, structural characterization and cytotoxic activity of organotin derivatives of indomethacin
Author(s) -
CamachoCamacho Carlos,
RojasOviedo Irma,
PazSandoval M. Angeles,
Cárdenas Jorge,
Toscano Alfredo,
Gielen Marcel,
Sosa Lidia Barrón,
Bártez Francisco Sánchez,
GraciaMora Isabel
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1366
Subject(s) - chemistry , hela , stereochemistry , indole test , nuclear magnetic resonance spectroscopy , proton nmr , cytotoxic t cell , ethyl acetate , in vitro , medicinal chemistry , organic chemistry , biochemistry
The synthesis, characterization and cytotoxic properties in vitro of tri‐ n ‐butyltin 1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 1 ), tri‐phenyltin 1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 2 ), tetra‐ n ‐butyltin[bis‐1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetato]distannoxane ( 3 ) and di‐ n ‐butyltin bis‐1‐(4‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1H‐indole‐3‐acetate ( 4 ) are described. These compounds have been characterized by 1 H, 13 C and 119 Sn NMR spectroscopy in solution and 119 Sn NMR in the solid state, infrared spectroscopy, elemental analysis and X‐ray diffraction for compound 1 . The growth inhibition effects of compounds 1–4 against the lung adenocarcinoma cell line SK‐LU‐1 as well as the cervical cancer cell line HeLa were determined. Compounds 1 and 2 exhibit cytotoxic activity, whereas compounds 3 and 4 are inactive. Copyright © 2008 John Wiley & Sons, Ltd.