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Synthesis, physico‐chemical and biological study of trialkylsiloxyalkyl amine coated iron oxide/oleic acid magnetic nanoparticles for the treatment of cancer
Author(s) -
Segal Izolda,
Zablotskaya Alla,
Lukevics Edmunds,
Maiorov Mikhail,
Zablotsky Dmitry,
Blums Elmars,
Shestakova Irina,
Domracheva Ilona
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1354
Subject(s) - chemistry , oleic acid , magnetite , magnetic nanoparticles , iron oxide nanoparticles , cytotoxicity , monolayer , nanoparticle , iron oxide , alkanolamine , amine gas treating , magnetite nanoparticles , in vitro , nuclear chemistry , chemical engineering , organic chemistry , biochemistry , metallurgy , materials science , aqueous solution , engineering
New original water‐soluble magnetic nanoparticles based on natural components, magnetite–oleic acid–biologically active silyl modified alkanolamine, were synthesized. Physico‐chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT‐1080), mouse hepatoma (MG‐22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non‐toxic, exhibit high NO‐induction ability and strongly change tumour cell morphology. Copyright © 2008 John Wiley & Sons, Ltd.