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Synthesis and spectroscopic characterization of new triorganotin(IV) complexes with the bis(1‐methyl‐1 H ‐imidazol‐2‐ylthio)acetate ligand: effects on trout erythrocyte components
Author(s) -
Alidori Simone,
Cocchioni Filippo,
Falcioni Giancarlo,
Fedeli Donatella,
Gioia Lobbia Gaia Emanuela,
Mancini Marilena,
Pellei Maura,
Santini Carlo
Publication year - 2008
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1348
Subject(s) - chemistry , ligand (biochemistry) , electrospray ionization , lipophilicity , stereochemistry , medicinal chemistry , sodium salt , nuclear magnetic resonance spectroscopy , metal , mass spectrometry , organic chemistry , inorganic chemistry , receptor , biochemistry , chromatography
Triorganotin(IV) derivatives containing the anionic ligand bis(1‐methyl‐1 H ‐imidazol‐2‐ylthio)acetate [(S‐tim) 2 CHCO 2 ] − were synthesized from the reaction between R 3 SnCl acceptors (R = Me and Ph) and the sodium salt of the ligand. Mono‐nuclear complexes of the type [(S‐tim) 2 CHCO 2 ]SnR 3 were obtained, which were fully characterized by elemental analyses and FT‐IR in the solid state, and by NMR ( 1 H, 13 C and 119 Sn) spectroscopy and electrospray ionization mass in solution. The toxic effects shown by these compounds on trout erythrocyte components showed that the toxicity of the organotin(IV) complexes depends on the nature and on the lipophilicity of the substituents on the metal centre. Copyright © 2007 John Wiley & Sons, Ltd.