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Synthesis, antitumor activity and crystal structure of the triphenyltin derivative of exo ‐7‐oxa‐bicyclo[2,2,1]hept‐5‐ene‐3‐ N ‐ p ‐tolylamide‐2‐acid
Author(s) -
Li Jinshan,
Ma Yongqiang,
Liu Runchang,
Li Jing
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.133
Subject(s) - chemistry , crystal structure , amide , stereochemistry , tin , ether , hydrogen bond , bicyclic molecule , monomer , dimer , intramolecular force , derivative (finance) , molecule , medicinal chemistry , crystallography , polymer , organic chemistry , financial economics , economics
The synthesis and crystal structure ofPh 3 SnO 2 CCHCHCH:CHCH(O)CHCONHC 6 H 4 CH 3 ·CH 2 Cl 2 are reported. The monomer unitsare bridged by the carbonyl oxygen of the amide group, thus forming a polymer in which each tin atom is best described as having a distorted five‐coordinate geometry. There is a relatively strong intramolecular hydrogen bond between the amide hydrogen and the ether oxygen. The in vitro antitumor activities of the title compound against HL‐60, BGC‐823, Bel‐7402, SKOV3, KB and Hela tumor lines are reported. The title compound shows a distinct advantage when the metal (tin) is introduced into the acid.Copyright © 2001 John Wiley & Sons, Ltd.