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Cyanosilylation of carbonyl compounds catalyzed by sodium L ‐histidine
Author(s) -
George Soney C.,
Kim Sung Soo,
Rajagopal Gurusamy
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1278
Subject(s) - chemistry , catalysis , yield (engineering) , histidine , salt (chemistry) , organic chemistry , sodium salt , combinatorial chemistry , inorganic chemistry , materials science , metallurgy , enzyme
Abstract An efficient protocol for the addition of trimethyl silanecarbonitrile to carbonyl compounds by employing 1 mol% of L ‐histidine sodium salt alone as the catalyst is presented. A variety of aromatic, aliphatic and cyclic carbonyl compounds have been converted into the corresponding trimethylethers in excellent yield (up to 99%) under mild conditions. Copyright © 2007 John Wiley & Sons, Ltd.