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Synthesis, characterization and in vitro cytotoxicity of palladium(II) complexes with mixed ligands. X‐ray diffraction study of C 31 H 36 ClNPPdS 2
Author(s) -
Shaheen Farkhanda,
Badshah Amin,
Gielen Marcel,
Gieck Christine,
de Vos Dick
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1245
Subject(s) - chemistry , cytotoxicity , denticity , dithiocarbamate , aspergillus fumigatus , stereochemistry , ligand (biochemistry) , palladium , nuclear chemistry , medicinal chemistry , in vitro , crystallography , crystal structure , organic chemistry , biochemistry , receptor , microbiology and biotechnology , biology , catalysis
Pd(II) complexes with organophosphines and dithiocarbamates derivatives of α‐amino acids were synthesized by reacting N , N ‐dicyclohexyldithiocarbamate (DCHDTC, compounds 1 – 3 ) and N ‐methylcyclohexyldithiocarbamate (MCHDTC, compounds 4 – 6 ) with (R 3 P) 2 PdCl 2 (R = Ph, o ‐tolyl, Ph 2 Cl) in a 1:1 molar ratio. The complexes were characterized by elemental analyses, FT‐IR, multinuclear ( 1 H, 13 C and 31 P) NMR and single X‐ray crystallography, showing that the dithiocarbamate acts as a bidentate ligand and binds to Pd(II) via two sulfur atoms, resulting in a square planar geometry around Pd(II). The cytotoxicity of compounds 2, 3 and 4 was determined in vitro against six human tumour cell lines, MCF7, EVSA‐T, WIDR, IGROV, M19 MEL, A498 and H226. Compounds 3 and 4 showed a moderate to low cytotoxicity, whereas compound 2 exhibited a very low cytotoxicity. The results of antifungal assays showed that compounds 1 – 6 possess antifungal activity against Fusarium moniliformes, Fusarium saolani, Mucor sp., Aspergillus niger and Aspergillus fumigatus. The anti‐inflammatory screening results of 1–6 are quite similar to those observed for the standard drug Declofenac at 10 mg kg −1 , which inhibited the odema by 74% after 4 h. Copyright © 2007 John Wiley & Sons, Ltd.