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Diethyl‐ and dibutyltin dihalide complexes of 1‐methyl‐2(3 H )‐imidazolinethione: synthesis, structure and antibacterial activity
Author(s) -
Casas J. S.,
Martínez E. García,
Jorge M. L.,
Russo U.,
Sánchez A.,
González A. Sánchez,
Seoane R.,
Sordo J.
Publication year - 2001
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.124
Subject(s) - chemistry , antibacterial activity , bacillus subtilis , octahedron , crystal structure , raman spectroscopy , stereochemistry , medicinal chemistry , tin , mass spectrometry , chlorine atom , sulfur , escherichia coli , nuclear chemistry , crystallography , organic chemistry , bacteria , biochemistry , genetics , physics , chromatography , gene , optics , biology
The compounds [SnR 2 X 2 (Hmimt)] (R = Et, Bu; X = Cl, Br; Hmimt = 1‐methyl‐2(3 H )‐imidazolinethione) and [SnEt 2 X 2 (Hmimt) 2 ] (X = Cl, Br) have been prepared and characterized by elemental analysis, mass spectrometry and IR, Raman, Mössbauer and NMR ( 1 H, 13 C and 119 Sn) spectroscopy. An X‐ray study of the crystal structure of [SnEt 2 Cl 2 (Hmimt) 2 ] shows all‐ trans octahedral stereochemistry with the tin atom coordinated to two ethyl carbon atoms, two chlorine atoms and the sulfur atoms of the two Hmimt ligands. Hmimt exhibits antibacterial activity against Bacillus subtilis (MIC = 6.25 μg ml −1 ), and all the complexes inhibit the growth of Escherichia coli and Staphylococcus aureus as well as B. subtilis , with MIC values of 12.5 μg ml −1 , 6.25 μg ml −1 and 3.12 μg ml −1 respectively, for the most active complex, [SnBu 2 Cl 2 (Hmimt)]. Only [SnEt 2 Cl 2 (Hmimt)] shows activity against Pseudomonas aeruginosa (MIC = 50 μg ml −1 ). Copyright © 2001 John Wiley & Sons, Ltd.