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The antispermatogenic activity of some phenylbismuth(III) O , O ′‐dialkyldithiophosphates
Author(s) -
Sharma Pankaj K.,
Rehwani H.,
Gupta R. S.,
Singh Y. P.
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1238
Subject(s) - chemistry , benzene , ligand (biochemistry) , medicinal chemistry , population , testosterone (patch) , stoichiometry , stereochemistry , medicine , biochemistry , organic chemistry , receptor , demography , sociology
Ten dialkyldithiophosphate derivatives of phenylbismuth(III) of the type, Ph (3– n ) Bi[S(S)P(OR) 2 ] n [where n = 1; R = Me( 1 ), Et( 2 ), Pri( 3 ), Pr n ( 4 ) and Bu n ( 5 ); n = 2; R = Me( 6 ), Et( 7 ), Pr i ( 8 ), Pr n ( 9 ) and Bu n ( 10 )] have been synthesized by the reactions of triphenylbismuth(III) with corresponding dialkyldithiophosphoric acids in 1:1 and 1:2 stoichiometric ratios, respectively, in stirred benzene solution. The newly synthesized brown colored compounds, 1–10 have been characterized by elemental analyses, molecular weight measurements, IR and NMR ( 1 H, 13 C and 31 P) spectral studies. The ligand diethyldithiophosphoric acid, [(C 2 H 5 O) 2 P(S)SH], and its organobismuth(III) derivatives, compounds 2 and 7 were administered to adult male rats by oral gavage at the dose of 25 mg per kg body weight per day, for 60 days, and their effects were evaluated and compared for changes in testicular morphology, circulatory concentrations of testosterone, FSH and LH, sperm dynamics, fertility index and testicular cell population dynamics. Copyright © 2007 John Wiley & Sons, Ltd.