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Mono‐ and heterodi‐nuclear complexes of aluminium: synthesis, characterization and antifungal activity
Author(s) -
Vajpayee Vaishali,
Singh Y. P.,
Nandani Durgesh,
Batra Amla
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1230
Subject(s) - chemistry , ligand (biochemistry) , medicinal chemistry , aspergillus flavus , carbon 13 nmr , nuclear chemistry , molar ratio , antifungal , aluminium , mass spectrum , aspergillus niger , benzene , nmr spectra database , stereochemistry , proton nmr , base (topology) , organic chemistry , spectral line , catalysis , medicine , ion , mathematical analysis , biochemistry , physics , receptor , food science , mathematics , dermatology , astronomy
Abstract Some new types of mononuclear derivatives, AlL(1–4)L(1–4)H ( 1a–1d ) of aluminium were synthesized by the reaction of Al(OPr i ) 3 and LH 2 [XC(NYOH)CHC(R)OH], X = CH 3 , Y = (CH 2 ) 2 , R = CH 3 (L1H 2 ); X = C 6 H 5 , Y = (CH 2 ) 2 , R = CH 3 (L2H 2 ); X = CH 3 , Y = (CH 2 ) 3 , R = CH 3 (L3H 2 ); X = C 6 H 5 , Y = (CH 2 ) 3 , R = CH 3 (L4H 2 ) in 1:2 molar ratio in refluxing benzene. Reactions of AlL(1–4)L(1–4)H with hexamethyldisilazane in 2:1 molar ratio yielded some new ligand bridged heterodinuclear derivatives AlL(1–4)L(1–4)SiMe 3 ( 2a – 2d ). All these newly synthesized derivatives were characterized by elemental analysis and molecular weight measurements. Tentative structures were proposed on the basis of IR and NMR spectra ( 1 H, 13 C,27Al and 29 Si) and FAB‐mass studies. Schiff base ligands and their mono‐ and heterodi‐nuclear derivatives with aluminium have been screened for fungicidal activities. These compounds showed significant antifungal activity against Aspergillus niger and A. flavus . Copyright © 2007 John Wiley & Sons, Ltd.