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Synthesis, characterization and in vitro cytotoxicity of homobimetallic complexes of palladium(II) with 2‐thiouracil ligands. Crystal structure of [Pd 2 (TU)(PPh 3 ) 3 Cl 2 ]
Author(s) -
Shaheen Farkhanda,
Badashah Amin,
Gielen Marcel,
Marchio L.,
de Vos Dick,
Kaleem Khosa M.
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1227
Subject(s) - chemistry , moiety , bimetallic strip , palladium , homonuclear molecule , stereochemistry , crystal structure , ligand (biochemistry) , denticity , crystallography , metal , medicinal chemistry , molecule , catalysis , organic chemistry , biochemistry , receptor
Square planar metallic and homonuclear bimetallic complexes of Pd(II) with 2‐thiouracil (HTU) and organophosphines have been synthesized and characterized by FT‐IR and multinuclear 1 H, 13 C, 31 P NMR spectroscopy. The thiouracil ligand TU acts as bidentate, is bound through the thioxo moiety and the endo amino group and forms a bridge between a PdCl(R 3 P) and a PdCl(R 3 P) 2 moiety [R 3 P = Ph 3 P ( o ‐tolyl) 3 P, ClPh 2 P] in the homonuclear bimetallic complexes. The square planar geometry around Pd(II) has been confirmed for these complexes by a single‐crystal X‐ray diffraction study of compound 1 , [Pd 2 (TU)(PPh 3 ) 3 Cl 2 ]. These compounds were also screened against human tumor cell lines and showed promising in vitro cytotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.