Premium
Synthesis, characterization and cytotoxicity evaluation of new cerium(III), lanthanum(III) and neodymium(III) complexes
Author(s) -
Kostova I.,
Momekov G.
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1205
Subject(s) - chemistry , cerium , lanthanum , neodymium , denticity , inorganic chemistry , nuclear chemistry , metal , cytotoxicity , lanthanide , medicinal chemistry , ion , organic chemistry , laser , biochemistry , physics , optics , in vitro
Complexes of cerium(III), lanthanum(III) and neodymium(III) with coumarin‐3‐carboxylic acid (HCCA) were synthesized by mixing of equimolar amounts of the respective metal nitrates and coumarin‐3‐carboxylic acid in ethanol. The complexes were characterized and identified by elemental analysis, IR and Raman spectroscopy. DTA and TGA were applied to study the compositions of the compounds. The vibrational study showed bidentate coordination of CCA − to Ln(III) ions through the carbonyl oxygen and the carboxylic oxygen atoms. The newly synthesized compounds were assayed for cytotoxicity against SKW‐3, HL‐60 and Reh cells. The complexes of cerium(III) and lanthanum(III) showed marginal cytotoxic activity against SKW‐3 and Reh cells as compared with the inorganic salts at concentration 200 µ M . The complex of neodymium(III) induced approximately 50% reduction of the survival HL‐60 and SKW‐3 cells at concentration 200 µ M . Copyright © 2007 John Wiley & Sons, Ltd.