Premium
Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set
Author(s) -
Zablotskaya Alla,
Segal Izolda,
Lukevics Edmunds,
Belyakov Sergey,
Spies Hartmut
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1201
Subject(s) - chemistry , denticity , rhenium , ligand (biochemistry) , methylene , tetrahydroisoquinoline , thiol , stereochemistry , crystallography , medicinal chemistry , crystal structure , inorganic chemistry , organic chemistry , biochemistry , receptor
Abstract New oxorhenium complexes with 3‐methylazapentane‐1,5‐dithiolate (SNMeS) and thiol functionalized monodentate tetrahydroquinolyl and tetrahydroisoquinolyl derivatives have been synthesized by simultaneous reaction of [PPh 3 ] 2 [Re(O)Cl 3 ] with tridentate HSNMeSH and the corresponding N‐heterocycle containing thiol. The characterization of complexes involved elemental analysis, IR, 1 H and 13 C NMR spectroscopy and X‐ray crystallographic analysis. The nature of the heterocycle in monodentate ligand, even situated at the distance of two methylene group length, has been found to have a significant influence on the molecular conformation. Metal complexes were found to be active in psychotropic in vivo and cytotoxicity in vitro screening. Copyright © 2007 John Wiley & Sons, Ltd.