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Antifertility and antimicrobial studies of pharmaceutically important organolead(IV) complexes of phenanthrolines
Author(s) -
Chaudhary Ashu,
Mahajan Karuna,
Singh R. V.
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1182
Subject(s) - chemistry , phenanthroline , chelation , antimicrobial , ligand (biochemistry) , sperm motility , sperm , denticity , stereochemistry , amino acid , lead compound , metal , in vitro , crystallography , biochemistry , organic chemistry , receptor , biology , botany
The present study deals with a brief description of antifertility and antimicrobial aspects along with the spectral characterization of lead(IV) complexes. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs of an interesting class of biologically potent complexes on male albino rats at the dosages have been examined and discussed. Lead(IV) complexes have been synthesized using amino acids and 1,10‐phenanthroline, 4,7‐phenanthroline or 1,7‐phenanthroline. A series of di‐ and tri‐organolead(IV) [LPbR n L′] and [LPbClR n L′] complexes where, L = amino acid (tyrosine and phenylalanine) and L′ = 1, 10‐phenanthroline, 4,7‐phenanthroline or 1,7‐phenanthroline and n = 2 or 3 have been prepared by the conventional methods. Structure elucidation has been done by IR, UV, 1 H, 13 C and 207 Pb NMR spectroscopy. On the basis of spectral evidences, it has been concluded that the carboxylic acid of the amino acid is behaving as a monodentate ligand in all these complexes and the complexes are octahedral in shape with a coordination number six around the lead atom. The complexes have been screened against a number of fungi and bacteria to assess their growth inhibiting potential. Lead complexes incorporating the chelating 1,10‐phenanthroline ligand showed a range of activities. The metal free non‐chelating ligands 1,7‐phenanthroline and 4,7‐phenanthroline were inactive and the complexes derived from 1,7‐phenanthroline displayed only marginal activity. Copyright © 2006 John Wiley & Sons, Ltd.