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Synthesis of novel derivatives of closo ‐dodecaborate anion with azido group at the terminal position of the spacer
Author(s) -
Orlova Anna V.,
Kondakov Nikolay N.,
Kimel Boris G.,
Koov Leonid O.,
Koova Elena G.,
Sivaev Igor B.,
Bregadze Vladimir I.
Publication year - 2007
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1151
Subject(s) - chemistry , oxonium ion , azide , ion , group (periodic table) , combinatorial chemistry , molecule , medicinal chemistry , polymer chemistry , organic chemistry
Two novel azido‐derivatives of closo ‐dodecaborate anion with hydrophobic and hydrophilic spacers were prepared by reaction of tetrabutylammonium azide with cyclic oxonium derivatives of the closo ‐dodecaborate anion. The compounds prepared can be regarded as precursors of derivatives of closo ‐dodecaborate anion with amino group at the terminal position of a spacer or as building blocks for ‘click chemistry’, which are useful for preparation of various conjugates with targeting molecules. A concentration dependence of the 11 B NMR spectra of functionalized derivatives of closo ‐dodecaborate anion was discovered, which is of great importance for analytical purposes. Copyright © 2006 John Wiley & Sons, Ltd.