α‐Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: α‐chymotrypsin and trypsin | Zendy

Shibli Amal | Zendy; Smoum Reem | Zendy; Goldberg Israel | Zendy; Rubinstein Abraham | Zendy; Srebnik Morris | Zendy

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α‐Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: α‐chymotrypsin and trypsin

Author(s) -

Shibli Amal,

Smoum Reem,

Goldberg Israel,

Rubinstein Abraham,

Srebnik Morris

Publication year - 2006

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1095

Subject(s) - chemistry , chymotrypsin , boron , serine , trypsin , proteases , crystallography , stereochemistry , tetrahedron , tetrahedral molecular geometry , amino acid , crystal structure , oxygen atom , atom (system on chip) , enzyme , molecule , organic chemistry , biochemistry , computer science , embedded system

The first examples of α‐amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom. Copyright © 2006 John Wiley & Sons, Ltd.

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