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Synthesis, spectral and antimicrobial studies of diorganotin(IV)3(2′‐hydroxyphenyl)‐5‐(4‐substituted phenyl) pyrazolinates
Author(s) -
Tripathi U. N.,
Venubabu G.,
Safi Ahmad Mohd.,
Rao Kolisetty S. S.,
Srivastava A. K.
Publication year - 2006
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1074
Subject(s) - chemistry , denticity , medicinal chemistry , pyrazoline , ligand (biochemistry) , stereochemistry , proton nmr , anhydrous , octahedron , molar ratio , sodium salt , nuclear chemistry , crystallography , crystal structure , inorganic chemistry , organic chemistry , biochemistry , receptor , catalysis
Diorganotin(IV) dipyrazolinates of the type R 2 Sn(C 15 H 12 N 2 OX) 2 [where C 15 H 12 N 2 OX = 3(2′‐Hydroxyphenyl)‐5(4‐X‐phenyl)pyrazoline {where X = H ( a ); CH 3 ( b ); OCH 3 ( c ); Cl ( d ) and R = Me, Pr n and Ph}] have been synthesized by the reaction of R 2 SnCl 2 with sodium salt of pyrazolines in 1:2 molar ratio, in anhydrous benzene. These newly synthesized derivatives have been characterized by elemental analysis (C, H, N, Cl and Sn), molecular weight measurement as well as spectral [IR and multinuclear NMR ( 1 H, 13 C and 119 Sn)] studies. The bidentate behaviour of the pyrazoline ligands was confirmed by IR, 1 H and 13 C NMR spectral data. A distorted trans ‐octahedral structure around tin(IV) atom for R 2 Sn(C 15 H 12 N 2 OX) 2 has been suggested. The free pyrazoline and diorganotin(IV) dipyrazolinates have also been screened for their antibacterial and antifungal activities. Some diorganotin(IV) dipyrazolinates exhibit higher antibacterial and antifungal effect than free ligand and some of the antibiotics. Copyright © 2006 John Wiley & Sons, Ltd.