Efficient iridium and rhodium‐catalyzed asymmetric transfer hydrogenation using 9‐amino(9‐deoxy)  cinchona  alkaloids as chiral ligands | Zendy

He Wei | Zendy; Liu Peng | Zendy; Le Zhang Bang | Zendy; Li Sun Xiao | Zendy; Zhang Sheng Yong | Zendy

Premium

Efficient iridium and rhodium‐catalyzed asymmetric transfer hydrogenation using 9‐amino(9‐deoxy) cinchona alkaloids as chiral ligands

Author(s) -

He Wei,

Liu Peng,

Le Zhang Bang,

Li Sun Xiao,

Zhang Sheng Yong

Publication year - 2006

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.1055

Subject(s) - chemistry , iridium , rhodium , catalysis , transfer hydrogenation , cinchona alkaloids , cinchona , asymmetric hydrogenation , ligand (biochemistry) , organic chemistry , enantioselective synthesis , combinatorial chemistry , medicinal chemistry , ruthenium , biochemistry , receptor

9‐Amino (9‐deoxy) cinchona alkaloids, derived from natural cinchona alkaloids, were applied in asymmetric transfer hydrogenation in both iridium and rhodium catalytic systems using i ‐propanol as the hydrogen source. A series of aromatic ketones was examined, and good to excellent conversions and enantioselectivities were observed. The best results were achieved using 9‐amino(9‐deoxy) epicinchonine 2a as the ligand and [Ir(COD)Cl] 2 as the metal precursor, and for the isobutylphenone, the conversion and enantioselectivity were obtained in 90 and 97% e.e. respectively. Copyright © 2006 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research