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Synthesis, spectroscopic characterization and in vitro studies of antimicrobial activity of bis (diorganodithiocarbamato)organodithiocarbonatobismuth (III) complexes
Author(s) -
Chauhan H. P. S.,
Shaik N. M.,
Singh U. P.
Publication year - 2006
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1013
Subject(s) - chemistry , antimicrobial , antifungal , nuclear chemistry , antibacterial activity , elemental analysis , potassium , in vitro , chloride , stereochemistry , medicinal chemistry , organic chemistry , bacteria , microbiology and biotechnology , biochemistry , genetics , biology
A brief account of the synthesis, spectroscopic characterization and the antimicrobial (bacterial and fungal) behaviour of bis (diorganodithiocarbamato)organodithiocarbonatobismuth(III) complexes is presented. The reaction of bis (diorganodithiocarbamato)bismuth(III) chloride with potassium organodithiocarbonate in equimolar ratio yielded the corresponding mixed derivatives of the type [R′ 2 NCS 2 ] 2 BiS 2 COR [where, R′ = CH 3 and C 2 H 5 ; R = Et, Pr n , Pr i , Bu n and Bu i ]. These have been characterized by molecular weight determinations, melting points (only solid complexes) and elemental (C, H, N, S and Bi) analysis as well as spectral IR and NMR [ 1 H and 13 C] studies. The antibacterial and antifungal activities of the free ligands and their bismuth complexes were found in vitro by the disc diffusion method. The complexes showed good antibacterial and antifungal effect on some selected bacterial and fungal strains. The antimicrobial activities of two standard antibiotics (Chloroamphenicol and Terbinafin) were also measured and compared with these complexes. Copyright © 2005 John Wiley & Sons, Ltd.

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