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Synthesis, characterization and biological activity of diphenyltin(IV) complexes of N ‐(3,5‐dibromosalicylidene)‐α‐amino acid and their diphenyltin dichloride adducts
Author(s) -
Tian Laijin,
Shang Zhicai,
Zheng Xiaoliang,
Sun Yuxi,
Yu You,
Qian Bochu,
Liu Xueli
Publication year - 2006
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1005
Subject(s) - chemistry , adduct , trigonal bipyramidal molecular geometry , stereochemistry , ligand (biochemistry) , carboxylate , crystal structure , oxygen atom , tin , medicinal chemistry , hela , nmr spectra database , crystallography , molecule , organic chemistry , spectral line , biochemistry , receptor , physics , astronomy , cell
Diphenyltin(IV) complexes of N ‐(3,5‐dibromosalicylidene)‐α‐amino acid, Ph 2 Sn[3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(R)COO] (where R = H, Me, i ‐Pr, Bz), and their 1:1 adducts with diphenyltin dichloride, Ph 2 Sn[3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH(R)COO]·Ph 2 SnCl 2 , have been synthesized and characterized by elemental analysis, IR and NMR ( 1 H, 13 C and 119 Sn) spectra. The crystal structure of Ph 2 Sn[3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH( i ‐Pr)COO] shows a distorted trigonal bipyramidal geometry with the axial locations occupied by a carboxylate–oxygen and a phenolic–oxygen atom of the ligand, and that of Ph 2 Sn[3,5‐Br 2 ‐2‐OC 6 H 2 CHNCH( i ‐Pr)COO]·Ph 2 SnCl 2 reveals that the two tin atoms are joined via the carbonyl atom of the ligand to form a mixed organotin binuclear complex. Bioassay indicates that the compounds possess better cytotoxic activity against three human tumor cell lines (HeLa, CoLo205 and MCF‐7) than cis ‐platin and moderate antibacterial activity against two bacteria ( E. coli and S. aureus) . Copyright © 2005 John Wiley & Sons, Ltd.