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Decoding Protein Gas‐Phase Stability with Alanine Scanning and Collision‐Induced Unfolding Ion Mobility Mass Spectrometry
Author(s) -
BellamyCarter Jeddidiah,
O'Grady Louisa,
Passmore Munro,
Jenner Matthew,
Oldham Neil J.
Publication year - 2021
Publication title -
analysis and sensing
Language(s) - English
Resource type - Journals
ISSN - 2629-2742
DOI - 10.1002/anse.202000038
Subject(s) - ion mobility spectrometry , alanine scanning , gas phase , cover (algebra) , mass spectrometry , alanine , chemistry , ion , collision , phase (matter) , analytical chemistry (journal) , mutagenesis , chromatography , computer science , biochemistry , amino acid , organic chemistry , mechanical engineering , computer security , engineering , mutation , gene
Invited for this month's cover are the collaborating groups of Professor Neil Oldham at the University of Nottingham and Dr. Matthew Jenner at the University of Warwick, UK. The cover picture shows collision induced unfolding (CIU) of an acyl carrier protein in the gas‐phase as measured by ion mobility spectrometry. The background shows a representation of the alanine scanning mutagenesis used to probe the importance of individual residues in stabilising the compact form of the protein. Read the full text of the article at 10.1002/anse.202000019.