Open AccessAdvances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows
Author(s) -
De Vos Jelle,
Stoll Dwight,
Buckenmaier Stephan,
Eeltink Sebastiaan,
Grinias James P.
Publication year - 2021
Publication title -
analytical science advances
Language(s) - English
Resource type - Journals
ISSN - 2628-5452
DOI - 10.1002/ansa.202100007
Subject(s) - workflow , instrumentation (computer programming) , injector , key (lock) , computer science , chromatography , process engineering , systems engineering , engineering , chemistry , mechanical engineering , database , operating system , computer security
The present contribution discusses recent advances in ultra‐high‐pressure liquid chromatography (UHPLC) and multi‐dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed‐up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.