Open AccessCombining ion chromatography with mass spectrometry and inductively coupled plasma‐mass spectrometry: Annual review 2020
Author(s) -
Bruggink Cees,
Jensen Detlef
Publication year - 2021
Publication title -
analytical science advances
Language(s) - English
Resource type - Journals
ISSN - 2628-5452
DOI - 10.1002/ansa.202000120
Subject(s) - inductively coupled plasma mass spectrometry , chemistry , mass spectrometry , chromatography , hydrophilic interaction chromatography , sample preparation , analytical chemistry (journal) , environmental chemistry , high performance liquid chromatography
The demand for analyzing low molecular weight polar and ionic components in body fluids, pharmaceutical formulations, food, environmental samples, and drinking water is increasing. Ion chromatography (IC) offers significant advantages over RPLC and HILIC due to a complementary chromatographic selectivity, a different retention mechanism, and a high tolerance toward complex matrices. A continuously regenerated membrane desalter simplifies the combination of IC‐applications with MS‐ or MS/MS‐detection, improving the sensitivity and specificity. Analytical workflows are streamlined, providing higher sample throughput. Combining IC with ICP‐MS simplifies the speciation analysis of inorganic and organic polar components. The knowledge about the distribution of an element among chemical species in a sample is essential due to significantly different toxicological or environmental properties. This annual review evaluates the literature published from late 2019 until November 2020.