Open AccessLack of association of a restriction fragment length polymorphism for serum amyloid P gene with reactive amyloidosis
Author(s) -
Harats Noam,
KluveBeckerman Barbara,
Skinner Martha,
Passo Murray,
Quinn Linda,
Benson Merrill D.
Publication year - 1989
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/anr.1780321021
Subject(s) - amyloidosis , restriction fragment length polymorphism , rheumatoid arthritis , genotype , serum amyloid a , polymorphism (computer science) , restriction fragment , juvenile rheumatoid arthritis , arthritis , gene , c reactive protein , gene polymorphism , restriction enzyme , medicine , amyloid (mycology) , immunology , biology , genetics , pathology , inflammation
The prevalence of a recently described restriction fragment length polymorphism using Msp I for the serum amyloid P gene was determined in 5 groups of patients. Patients with reactive (secondary) amyloidosis, juvenile rheumatoid arthritis, related inflammatory conditions, or juvenile rheumatoid arthritis with reactive amyloidosis, and healthy control subjects were found to be polymorphic for 8.8‐kb and 5.6‐kb gene fragments; they either had one or the other or both fragments. No significant differences were seen between these groups with relation to this polymorphism, and no correlation with the presence of reactive amyloidosis was observed.