Combination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case observations | Zendy

Shiroky J. B. | Zendy; Watts C. S. | Zendy; Neville C. | Zendy

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Combination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case observations

Author(s) -

Shiroky J. B.,

Watts C. S.,

Neville C.

Publication year - 1989

Publication title -

arthritis & rheumatism

Language(s) - English

Resource type - Journals

eISSN - 1529-0131

pISSN - 0004-3591

DOI - 10.1002/anr.1780320916

Subject(s) - sulfasalazine , rheumatoid arthritis , medicine , methotrexate , morning stiffness , prednisone , toxicity , gastroenterology , surgery , psoriatic arthritis , disease , ulcerative colitis

Four patients with rheumatoid arthritis received a combination of methotrexate and sulfasalazine for a mean of 24 months (range 20–28 months). All 4 patients experienced clinical improvement, with a reduction in the number of involved joints and in morning stiffness. In all 3 patients who had previously taken methotrexate, we were able to reduce the dosage, and the prednisone dosage was reduced in 2 of 3 patients who had previously taken that drug. No serious toxicity was observed in any patient.

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