Open AccessCombination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case observations
Author(s) -
Shiroky J. B.,
Watts C. S.,
Neville C.
Publication year - 1989
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/anr.1780320916
Subject(s) - sulfasalazine , rheumatoid arthritis , medicine , methotrexate , morning stiffness , prednisone , toxicity , gastroenterology , surgery , psoriatic arthritis , disease , ulcerative colitis
Four patients with rheumatoid arthritis received a combination of methotrexate and sulfasalazine for a mean of 24 months (range 20–28 months). All 4 patients experienced clinical improvement, with a reduction in the number of involved joints and in morning stiffness. In all 3 patients who had previously taken methotrexate, we were able to reduce the dosage, and the prednisone dosage was reduced in 2 of 3 patients who had previously taken that drug. No serious toxicity was observed in any patient.