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Inside Cover: Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons (Angew. Chem. Int. Ed. 41/2021)
Author(s) -
Fujiyama Keisuke,
Kato Naoki,
Re Suyong,
Kinugasa Kiyomi,
Watanabe Kohei,
Takita Ryo,
Nogawa Toshihiko,
Hino Tomoya,
Osada Hiroyuki,
Sugita Yuji,
Takahashi Shunji,
Nagano Shingo
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202109381
Subject(s) - decalin , intramolecular force , chemistry , stereochemistry , stereoselectivity , cycloaddition , bicyclic molecule , yield (engineering) , materials science , organic chemistry , catalysis , metallurgy
A linear hydrocarbon chain containing a diene and a dienophile is folded and transformed into a decalin scaffold by intramolecular [4+2] cycloaddition. The substrates are folded oppositely but bind in the same orientation to the pockets of a pair of Diels–Alderases to yield enantiomeric decalin skeletons, as reported by Naoki Kato, Shunji Takahashi, Shingo Nagano, and co‐workers in their Research Article on page 22401.