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Cover Picture: Expedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis (Angew. Chem. Int. Ed. 40/2021)
Author(s) -
Biswas Sovan,
Van Steijvoort Ben F.,
Waeterschoot Marjo,
Bheemireddy Narendraprasad Reddy,
Evano Gwilherm,
Maes Bert U. W.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202109132
Subject(s) - tandem , bicyclic molecule , catalysis , combinatorial chemistry , chemistry , organocatalysis , drug discovery , nanotechnology , organic chemistry , enantioselective synthesis , materials science , composite material , biochemistry
Escape from flatland . Increased saturation (fraction of sp 3 ) is more likely to be successful when moving compounds through the drug development pipeline. Bridged nitrogen heterocycles have a huge potential in drug discovery, although long synthetic sequences are typically required. New step‐economic and selective organic syntheses are therefore highly sought after. Bert U. W. Maes et al. describe in their Research Article on page 21988 the synthesis of the normorphan skeleton through challenging tandem catalysis. Cover design by Joris Snaet.