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Controlling Coagulation in Blood with Red Light
Author(s) -
Müller Patricia,
Sahlbach Marlen,
Gasper Simone,
Mayer Günter,
Müller Jens,
Pötzsch Bernd,
Heckel Alexander
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202108468
Subject(s) - aptamer , coagulation , linker , red light , human blood , chemistry , thrombin generation , blood clotting , thrombin , nanotechnology , biophysics , combinatorial chemistry , computer science , platelet , materials science , biomedical engineering , medicine , biology , microbiology and biotechnology , physiology , botany , psychiatry , immunology , operating system
Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin‐binding aptamer with a red‐light photocleavable linker derived from Cy7 by Cu‐catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.