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Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER
Author(s) -
Korchak Sergey,
Kaltschnee Lukas,
Dervisoglu Riza,
Andreas Loren,
Griesinger Christian,
Glöggler Stefan
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202108306
Subject(s) - spins , signal (programming language) , nuclear magnetic resonance , hyperpolarization (physics) , sensitivity (control systems) , molecule , resonance (particle physics) , dipole , electromagnetic coil , magnetic resonance imaging , chemistry , materials science , physics , nuclear magnetic resonance spectroscopy , computer science , condensed matter physics , atomic physics , electronic engineering , engineering , medicine , organic chemistry , quantum mechanics , radiology , programming language
Abstract Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity: Only a few spins contribute to the overall signal. To overcome this limitation, hyperpolarization methods were developed that increase signals several times beyond the normal/thermally polarized signals. The ideal case would be a universal approach that can signal enhance the complete sample of interest in solution to increase detection sensitivity. Here, we introduce a combination of para‐hydrogen enhanced magnetic resonance with the phenomenon of the RASER: Large signals of para‐hydrogen enhanced molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in‐phase signal. These molecules directly interact with other compounds via dipolar couplings and enhance their signal. We demonstrate that this is not only possible for solvent molecules but also for an amino acid.