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Inside Back Cover: Particle‐by‐Particle In Situ Characterization of the Protein Corona via Real‐Time 3D Single‐Particle‐Tracking Spectroscopy (Angew. Chem. Int. Ed. 41/2021)
Author(s) -
Tan Xiaochen,
Welsher Kevin
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202107758
Subject(s) - particle (ecology) , nanoparticle , characterization (materials science) , tracking (education) , corona (planetary geology) , microscope , particle size , nanotechnology , cover (algebra) , materials science , spectroscopy , chemistry , analytical chemistry (journal) , physics , optics , engineering , chromatography , mechanical engineering , psychology , pedagogy , oceanography , quantum mechanics , geology , astrobiology , venus
A high‐speed 3D microscope has been developed to quantify the nanoparticle protein corona at the single‐particle level. As presented by Xiaochen Tan and Kevin Welsher in their Research Article on page 22359, the microscope can “lock on” to freely diffusing nanoparticles to quantify the tightly bound “hard” and dynamic “soft” corona layers. This method can analyze single nanoparticles in the presence of significant protein background signals, opening the possibility for quantifying the protein corona in vivo.
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