Premium
Inside Cover: Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp. (Angew. Chem. Int. Ed. 34/2021)
Author(s) -
Tyurin Anton P.,
Alferova Vera A.,
Paramonov Alexander S.,
Shuvalov Maxim V.,
Kudryakova Gulnara K.,
Rogozhin Eugene A.,
Zherebker Alexander Y.,
Brylev Vladimir A.,
Chistov Alexey A.,
Baranova Anna A.,
Biryukov Mikhail V.,
Ivanov Igor A.,
Prokhorenko Igor A.,
Grammatikova Natalia E.,
Kravchenko Tatyana V.,
Isakova Elena B.,
Mirchink Elena P.,
Gladkikh Elena G.,
Svirshchevskaya Elena V.,
Mardanov Andrey V.,
Beletsky Aleksey V.,
Kocharovskaya Milita V.,
Kulyaeva Valeriya V.,
Shashkov Alexander S.,
Tsvetkov Dmitry E.,
Nifantiev Nikolay E.,
Apt Alexander S.,
Majorov Konstantin B.,
Efimova Svetlana S.,
Ravin Nikolai V.,
Nikolaev Evgeny N.,
Ostroumova Olga S.,
Katrukha Genrikh S.,
Lapchinskaya Olda A.,
Dontsova Olga A.,
Terekhov Stanislav S.,
Osterman Ilya A.,
Shenkarev Zakhar O.,
Korshun Vladimir A.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202107693
Subject(s) - int , cover (algebra) , stereochemistry , bacteria , gene cluster , streptomyces , mode of action , gene , chemistry , microbiology and biotechnology , biology , biochemistry , genetics , computer science , engineering , mechanical engineering , operating system
A new lipoglycopeptide antibiotic family with unique structural features and pronounced activity against Gram‐positive bacteria is described by Stanislav S. Terekhov, Zakhar O. Shenkarev, Vladimir A. Korshun, and co‐workers in their Research Article on page 18694. Gausemycins are intrinsically fluorescent compounds with an original mode of antibacterial action. Analysis of the biosynthetic gene cluster revealed unusual enzymology, involved in the formation of a previously unknown nonproteinogenic amino acid.