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Photoelectron Circular Dichroism in the Photodetachment of Amino Acid Anions
Author(s) -
Krüger Peter,
Weitzel KarlMichael
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202107150
Subject(s) - chirality (physics) , chemistry , circular dichroism , electrospray ionization , molecule , analyte , x ray photoelectron spectroscopy , ionization , mass spectrometry , chemical physics , crystallography , organic chemistry , ion , nuclear magnetic resonance , physics , chromatography , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
The chirality of chemical compounds is of undisputed importance in science and technology. In particular with respect to pharmacological application most molecules of interest cannot be accessed by the powerful techniques developed in recent years for gas phase analytes. Here, we demonstrate that the combination of electrospray ionization (ESI) with the detection of photoelectron circular dichroism (PECD) provides access to chirality information applicable to molecular materials with negligible vapor pressure, for example, amino acids. To this end, glutamic acid and 3,4‐dihydroxyphenylalanine (DOPA) have been electrosprayed into the source of a chirality spectrometer, where photodetachment is enforced and the PECD is detected. The technique can be expected to be conceptually applicable to all chemical systems with chirality based on molecular properties.