Premium
Back Cover: Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades (Angew. Chem. Int. Ed. 34/2021)
Author(s) -
Mattey Ashley P.,
Ford Grayson J.,
Citoler Joan,
Baldwin Christopher,
Marshall James R.,
Palmer Ryan B.,
Thompson Matthew,
Turner Nicholas J.,
Cosgrove Sebastian C.,
Flitsch Sabine L.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202107128
Subject(s) - flow chemistry , continuous flow , cover (algebra) , chemistry , biocatalysis , amine gas treating , combinatorial chemistry , flow (mathematics) , nanotechnology , catalysis , organic chemistry , biochemical engineering , materials science , engineering , physics , reaction mechanism , mechanical engineering , mechanics
Compartmentalised flow reactors allow biocatalytic cascades that would be impossible using standard methods, as described by Sebastian C. Cosgrove, Sabine L. Flitsch, and co‐workers in their Research Article on page 18660. Carbonyl intermediates were continuously generated via biocatalytic oxidation, then converted into different amine products using immobilised aminating enzymes. The use of flow equipment allowed exquisite control of the paths and enabled a range of new biocatalytic cascades to be constructed, paving the way for fully automated continuous biocatalytic cascades.