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Catalytic System‐Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
Author(s) -
Fang Feifei,
Hu Shulei,
Li Chunpu,
Wang Qian,
Wang Run,
Han Xu,
Zhou Yu,
Liu Hong
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202105857
Subject(s) - annulation , catalysis , cascade reaction , tandem , chemistry , cascade , combinatorial chemistry , scope (computer science) , stereochemistry , organic chemistry , materials science , computer science , chromatography , composite material , programming language
A catalytic system‐controlled divergent reaction strategy was here reported to construct four types of intriguing spiroheterocyclic skeletons from simple and readily available starting materials via a precise chemical bond activation/[ n +1] annulation cascade. The tetraazaspiroheterocyclic and trizazspiroheterocyclic scaffolds could be independently constructed by a selective N−N bond activation/[ n +1] annulation cascade, a C(sp 2 )‐H activation/[4+1] annulation and a novel tandem C(sp 2 )‐H/C(sp 3 )−H bond activation/[4+1] annulation strategy, along with a broad scope of substrates, moderate to excellent yields and valuable transformations. More importantly, in these transformations, we are the first time to capture a N−N bond activation and a C(sp 3 )−H bond activation of pyrazolidinones under different catalytic system.