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Enantioselective Addition of Pyrazoles to Dienes **
Author(s) -
Jiu Alexander Y.,
Slocumb Hannah S.,
Yeung Charles S.,
Yang XiaoHui,
Dong Vy M.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202105679
Subject(s) - enantioselective synthesis , chemistry , organic chemistry , catalysis
We report the first enantioselective addition of pyrazoles to 1,3‐dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd 0 ‐catalyzed ligand‐to‐ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.