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Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021)
Author(s) -
Brand Michael,
Wang Lei,
Agnello Stefano,
Gazzola Silvia,
Gall Flavio M.,
Raguž Luka,
Kaiser Marcel,
Schmidt Remo S.,
Ritschl Amélie,
Jelk Jennifer,
Hemphill Andrew,
Mäser Pascal,
Bütikofer Peter,
Adams Michael,
Riedl Rainer
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202104896
Subject(s) - antiprotozoal , mode of action , potency , int , cover (algebra) , pharmacology , biology , chemistry , in vitro , toxicology , biochemistry , engineering , computer science , mechanical engineering , operating system
Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more accessible and more selective antiprotozoal agents with broad efficacy and undetectable resistance.