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Inside Cover: Mechanochemical Release of Non‐Covalently Bound Guests from a Polymer‐Decorated Supramolecular Cage (Angew. Chem. Int. Ed. 24/2021)
Author(s) -
Küng Robin,
Pausch Tobias,
Rasch Dustin,
Göstl Robert,
Schmidt Bernd M.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202104888
Subject(s) - supramolecular chemistry , covalent bond , polymer , aqueous solution , supramolecular polymers , chemistry , cage , octahedron , polymer chemistry , star polymer , self assembly , nanotechnology , materials science , crystallography , molecule , organic chemistry , crystal structure , polymerization , mathematics , combinatorics
A supramolecular coordination cage in the center of a star‐shaped water‐soluble polymer responds to ultrasonication‐induced shear force in solution. As reported by Robert Göstl, Bernd M. Schmidt, and co‐workers in their Communication on page 13626, the octahedral Pd cage (blue panels) bearing polymer chains (red) on each vertex (metallic) encapsulates pharmaceutically active cargo within its hydrophobic nanocavity and is activated by sonication in aqueous solution, with complete cargo release upon rupture.