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One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles
Author(s) -
Watanabe Kodai,
Kaizawa Noya,
Ree Brian J.,
Yamamoto Takuya,
Tajima Kenji,
Isono Takuya,
Satoh Toshifumi
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202103969
Subject(s) - janus , copolymer , polymer , nanoparticle , polystyrene , nanotechnology , materials science , chemistry , composite material
Developing an efficient and versatile process to transform a single linear polymer chain into a shape‐defined nanoobject is a major challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in a synthetic polymer system. In this study, we performed one‐shot intrablock cross‐linking of linear block copolymers (BCPs) to realize single‐chain nanoparticles (SCNPs) with two chemically compartmentalized domains (Janus‐shaped SCNPs). Detailed structural characterizations of the Janus‐shaped SCNP composed of polystyrene‐block‐poly(glycolic acid) revealed its compactly folded conformation and compartmentalized block localization, similar to the self‐folded tertiary structures of natural proteins. Versatility of the one‐shot intrablock cross‐linking was demonstrated using several different BCP precursors. In addition, the Janus‐shaped SCNP produce miniscule microphase‐separated structures.