Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis | Zendy

Moock Daniel | Zendy; Wagener Tobias | Zendy; Hu Tianjiao | Zendy; Gallagher Timothy | Zendy; Glorius Frank | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis

Author(s) -

Moock Daniel,

Wagener Tobias,

Hu Tianjiao,

Gallagher Timothy,

Glorius Frank

Publication year - 2021

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.202103910

Subject(s) - stereocenter , cascade , rhodium , catalysis , carbene , ruthenium , chemistry , combinatorial chemistry , homogeneous , molecule , sequence (biology) , organic chemistry , stereochemistry , enantioselective synthesis , mathematics , chromatography , biochemistry , combinatorics

We report an enantio‐ and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one‐pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium‐N‐heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research