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Supramolecular Polymerization‐Induced Nanoassemblies for Self‐Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor
Author(s) -
Yang Kuikun,
Yu Guocan,
Yang Zhiqing,
Yue Ludan,
Zhang Xiangjun,
Sun Chen,
Wei Jianwen,
Rao Lang,
Chen Xiaoyuan,
Wang Ruibing
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202103721
Subject(s) - supramolecular chemistry , chemistry , nanomedicine , combinatorial chemistry , biophysics , nanotechnology , nanoparticle , materials science , organic chemistry , crystal structure , biology
The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H 2 O 2 level in tumor tissues. Herein, we developed a supramolecular nanoparticle via a simple one‐step supramolecular polymerization‐induced self‐assembly process using platinum (IV) complex‐modified β‐cyclodextrin‐ferrocene conjugates as supramolecular monomers. The supramolecular nanoparticles could dissociate rapidly upon exposure to endogenous H 2 O 2 in the tumor and release hydroxyl radicals as well as platinum (IV) prodrugs in situ, which is reduced into cisplatin to significantly promote the generation of H 2 O 2 in the tumor tissue. Thus, the supramolecular nanomedicine overcomes the limitation of conventional chemodynamic therapy via the self‐augmented cascade radical generation and drug release. In addition, dissociated supramolecular nanoparticles could be readily excreted from the body via renal clearance to effectively avoid systemic toxicity and ensure long term biocompatibility of the nanomedicine. This work may provide new insights on the design and development of novel supramolecular nanoassemblies for cascade chemo/chemodynamic therapy.