Premium
Cover Picture: Concise Asymmetric Syntheses of Streptazone A and Abikoviromycin (Angew. Chem. Int. Ed. 19/2021)
Author(s) -
Wørmer Gustav J.,
Villadsen Nikolaj L.,
Nørby Peter,
Poulsen Thomas B.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202103581
Subject(s) - cover (algebra) , natural product , chemistry , int , reactivity (psychology) , stereochemistry , combinatorial chemistry , nanotechnology , computer science , materials science , engineering , medicine , alternative medicine , pathology , operating system , mechanical engineering
From thought to action . In the creative process of natural product synthesis, the mental movement of atoms to their desired positions encounters the boundaries of real reactivity. In their Communication on page 10521, Thomas B. Poulsen et al. report the highly efficient assembly of a series of alkaloid natural products in the streptazone and abikoviromycin family. Precise orchestration of (asymmetric) redox manipulations and rapid scaffold assembly via a selective Pauson–Khand reaction enabled the syntheses.