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Chirogenesis and Amplification of Molecular Chirality Using Optical Vortices
Author(s) -
Sakamoto Masami,
Uemura Naohiro,
Saito Rei,
Shimobayashi Haruna,
Yoshida Yasushi,
Mino Takashi,
Omatsu Takashige
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202103382
Subject(s) - homochirality , chirality (physics) , nucleation , optical vortex , crystallization , materials science , crystal (programming language) , vortex , chemical physics , optical tweezers , chiral symmetry breaking , crystallography , optics , chemistry , physics , symmetry breaking , enantiomer , stereochemistry , organic chemistry , thermodynamics , programming language , quantum mechanics , computer science , nambu–jona lasinio model
The study of chirogenesis of organic molecules is important to elucidate the origin of the homochirality of biomolecules on Earth. Here, we have accomplished chiral symmetry breaking from a racemate using optical vortices with orbital angular momentum and a helical wavefront. We propose a new methodology of asymmetric transformation by the combination of enantioselective crystal nucleation by irradiation with optical vortices and crystallization‐induced dynamic optical resolution of conglomerate crystals. Chiral green vortices generated using a spiral phase plate (SPP) with a 532 nm CW‐laser were used to irradiate a supersaturated solution of a racemic isoindolinone, leading to crystal nucleation. The handedness of the crystals were controlled by the winding direction of the chiral optical vortices. The molecular chirality of the isoindolinone was then amplified by dynamic crystallization.