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Potent Cyclic Tetrapeptide for Lead Detoxification
Author(s) -
Mohammed Tagwa A.,
Meier Christoph M.,
Kalvoda Tadeáš,
Kalt Martina,
Rulíšek Lubomír,
Shoshan Michal S.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202103217
Subject(s) - tetrapeptide , detoxification (alternative medicine) , potency , peptide , chemistry , lead compound , toxicity , selectivity , pharmacology , combinatorial chemistry , toxicology , biochemistry , medicine , biology , in vitro , organic chemistry , alternative medicine , pathology , catalysis
Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state‐of‐the‐art drugs. The Pb‐peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning.