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A Light‐Operated Molecular Cable Car for Gated Ion Transport
Author(s) -
Wang Chenxi,
Wang Shunkang,
Yang Huiting,
Xiang Yanxin,
Wang Xuebin,
Bao Chunyan,
Zhu Linyong,
Tian He,
Qu DaHui
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102838
Subject(s) - azobenzene , molecular machine , ion transporter , isomerization , membrane , ion , lipid bilayer , bilayer , chemistry , molecular dynamics , materials science , chemical physics , biophysics , nanotechnology , molecule , computational chemistry , organic chemistry , catalysis , biochemistry , biology
Inspired by the nontrivial and controlled movements of molecular machines, we report an azobenzene‐based molecular shuttle PR2 , which can perform light‐gated ion transport across lipid membranes. The amphiphilicity and membrane‐spanning molecular length enable PR2 to insert into the bilayer membrane and efficiently transport K + (EC 50 =4.1 μ m ) through the thermally driven stochastic shuttle motion of the crown ether ring along the axle. The significant difference in shuttling rate between trans‐ PR2 and cis‐ PR2 induced by molecular isomerization enables a light‐gated ion transport, i.e., ON/OFF in situ regulation of transport activity and single‐channel current. This work represents an example of using a photoswitchable molecular machine to realize gated ion transport, which demonstrates the value of molecular machines functioning in biomembranes.