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Ruthenium‐Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides
Author(s) -
Liu Shiyao,
Tanabe Yoshiaki,
Kuriyama Shogo,
Sakata Ken,
Nishibayashi Yoshiaki
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102779
Subject(s) - enantioselective synthesis , phosphine , ruthenium , nucleophile , catalysis , chemistry , organic chemistry , phosphorus , substitution reaction , combinatorial chemistry , transition metal
The development of transition metal‐catalyzed enantioselective propargylic substitution reactions has gained much progress in recent years, however, no successful example with phosphorus‐centered nucleophiles has yet been reported until now. Herein, we report the first successful example of ruthenium‐catalyzed enantioselective propargylic substitution reactions of propargylic alcohols with diarylphosphine oxides as phosphorus‐centered nucleophiles. This synthetic approach provides a new method to prepare chiral phosphorus‐containing organic compounds.