z-logo
Premium
Metal Complex Lipids for Fluid–Fluid Phase Separation in Coassembled Phospholipid Membranes
Author(s) -
Ohtani Ryo,
Anegawa Yuka,
Watanabe Hikaru,
Tajima Yutaro,
Kinoshita Masanao,
Matsumori Nobuaki,
Kawano Kenichi,
Yanaka Saeko,
Kato Koichi,
Nakamura Masaaki,
Ohba Masaaki,
Hayami Shinya
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102774
Subject(s) - phospholipid , membrane , chemistry , phase (matter) , vesicle , crystallography , metal , fluorescence , analytical chemistry (journal) , chromatography , organic chemistry , biochemistry , optics , physics
We demonstrate a fluid–fluid phase separation in 1,2‐dimyristoyl‐ sn ‐glycero‐3‐phosphocholine (DMPC) membranes using a metal complex lipid of type [Mn(L1)] ( 1 ; HL1=1‐(2‐hydroxybenzamide)‐2‐(2‐hydroxy‐3‐formyl‐5‐hexadecyloxybenzylideneamino)ethane). Small amount of 1 produces two separated domains in DMPC, whose phase transition temperatures of lipids ( T c ) are both lower than that of the pristine DMPC. Variable temperature fluorescent microscopy for giant‐unilamellar vesicles of DMPC/ 1 hybrids demonstrates that visible phase separations remain in fluid phases up to 37 °C, which is clearly over the T c of DMPC. This provides a new dimension for the application of metal complex lipids toward controlling lipid distributions in fluid membranes.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here