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ZW800‐PEG: A Renal Clearable Zwitterionic Near‐Infrared Fluorophore for Potential Clinical Translation
Author(s) -
Yang Chengeng,
Wang Haoran,
Yokomizo Shinya,
Hickey Morgan,
Chang Hyejin,
Kang Homan,
Fukuda Takeshi,
Song Mi Young,
Lee Sang Yeul,
Park Jin Woo,
Bao Kai,
Choi Hak Soo
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102640
Subject(s) - fluorophore , peg ratio , indocyanine green , aqueous solution , fluorescence , materials science , photothermal therapy , chemistry , nanotechnology , medicine , organic chemistry , surgery , optics , physics , finance , economics
Near‐infrared (NIR) fluorescence imaging has advanced medical imaging and image‐guided interventions during the past three decades. Despite tremendous advances in imaging devices, surprisingly only a few dyes are currently available in the clinic. Previous fluorophores, ZW800‐1A and ZW800‐1C, significantly improved the poor performance of the FDA‐approved indocyanine green. However, ZW800‐1A is not stable in serum and ZW800‐1C induces severe stacking in aqueous media. To solve such dilemmas, ZW800‐PEG was designed by introducing a flexible yet stable thiol PEG linker. ZW800‐PEG shows high solubility in both aqueous and organic solvents, thus improving renal clearance with minimal binding to serum proteins during systemic circulation. The sulfide group on the meso position of the heptamethine core improves serum stability and physicochemical properties including the maximum emission wavelength shift to 800 nm, enabling the use of ZW800‐PEG for image‐guided interventions and augmenting photothermal therapy.